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NAVIGATE was evaluated from 2009-2014 in a cluster randomized controlled trial (RAISE-ETP). The RAISE-ETP team developed a comprehensive and integrated treatment intervention that they expected to:

  • Promote symptomatic recovery

  • Minimize disability

  • Maximize social, academic, and vocational functioning

  • Be capable of being delivered in real world settings utilizing current funding mechanisms


They assessed the overall clinical impact and cost-effectiveness of the intervention as compared to currently prevailing treatment approaches.  They conducted the comparison in non-academic, real world community treatment settings.


Outcomes of the Study:

  • Remained in treatment longer

  • Increased improvement in quality of life and psychopathology

  • Greater involvement in work and school

  • Median duration of untreated psychosis was 74 weeks


Participants with duration of untreated psychosis of

<74 weeks had greater improvement in quality of life and

psychopathology compared with those with longer duration

of untreated psychosis.




  • NAVIGATE provided greater improvement in symptoms and significantly greater improvement in real-world functioning, including social functioning and engagement in educational and vocational training

  • Readily implementable across a broad range of community-based mental health settings

  • More cost-effective compared to standard community care, driven by the anticipated enhanced health benefits and improvements in quality of life


Please refer to the RAISE Study page for more information. 


The RAISE Early Treatment Program for First Episode Psychosis: Background, Rationale, and Study Design  (Kane et al., 2015)


The NAVIGATE Program for First-Episode Psychosis: Rationale, Overview, and Description of Psychosocial Components  (Mueser et al., 2015)


Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2 Year Outcomes from the NIMH RAISE Early Treatment Program  (Kane et al., 2016)

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