NAVIGATE was evaluated from 2009-2014 in a cluster randomized controlled trial (RAISE-ETP). The RAISE-ETP team developed a comprehensive and integrated treatment intervention that they expected to:

  • Promote symptomatic recovery

  • Minimize disability

  • Maximize social, academic, and vocational functioning

  • Be capable of being delivered in real world settings utilizing current funding mechanisms

They assessed the overall clinical impact and cost-effectiveness of the intervention as compared to currently prevailing treatment approaches.  They conducted the comparison in non-academic, real world community treatment settings.


Outcomes of the Study:

  • Remained in treatment longer

  • Increased improvement in quality of life and psychopathology

  • Greater involvement in work and school

  • Median duration of untreated psychosis was 74 weeks


Participants with duration of untreated psychosis of

<74 weeks had greater improvement in quality of life and

psychopathology compared with those with longer duration

of untreated psychosis.



  • NAVIGATE provided greater improvement in symptoms and significantly greater improvement in real-world functioning, including social functioning and engagement in educational and vocational training

  • Readily implementable across a broad range of community-based mental health settings

  • More cost-effective compared to standard community care, driven by the anticipated enhanced health benefits and improvements in quality of life


Please refer to the website for more information: https://www.nimh.nih.gov/health/topics/schizophrenia/raise/raise-questions-and-answers.shtml


The RAISE Early Treatment Program for First Episode Psychosis: Background, Rationale, and Study Design (Kane et al., 2015)


The NAVIGATE Program for First-Episode Psychosis: Rationale, Overview, and Description of Psychosocial Components (Mueser et al., 2015)


Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2 Year Outcomes from the NIMH RAISE Early Treatment Program (Kane et al., 2016)